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KMID : 0360419700060020031
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Korean Journal of Pharmacology
1970 Volume.6 No. 2 p.31 ~ p.44
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Effect of Dietary Proteins on Exocrine Pancrease in rats
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Abstract
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In view of the great metabolic activity of the pancreas in the synthesis as well as secretion of digestive enzymes, deficiencies of dietary protein or amino acids through the defective protein supply can be expected to interfere with pancreatic function and also with structural integrity of the gland. Present study was investigated on the dietary regulation of the synthesis, secretion or morphologic pattern of the exocrine pancreas in rats fed a protein free, protein deficiency, low protein, protein sufficiency diets or diets containing gluten, gelatin or zein as a protein source.
Measurement of the enzyme content of the pancreas in rats fed with protein free diet showed a depressed synthesis from the first week and a marked depression particularly in amylase and lipase from the third week. A gradual disappearance of zymogen granules and diminution in the size of acinar cells were seen in first week and the changes became more pronounced in the third week when revealed a marked atrophy of the acini. Animals fed protein deficiency diets showed a great depression of the three pancreatic enzymes and a marked atrophic changes of the acini at the fourth week. In the low protein diet (8% casein) the pancreas revealed a slight atrophy of acini, however, no depression of the pancreatic enzyme content was seen even at the fourth week. The animals fed gelatin or zein diet showed a considerable weight loss, but organ weights were not much changed in comparing with casein group. The enzyme secretion was greatly depressed in animals fed gluten, gelatin or zein diet in contrast to the casein, and biliary-pancreatic juice volume was reduced significantly only in the zein diet. Atrophy of acinar cells and dissociation of acini in animals fed zein diet were marked and the less atrophic lesions were observed in gelatin group.
By these data the dietary protein levels or dietary defective proteins were intimately reflected on the either the function or morphologic integrity of the pancreas and it is confirmed that on a synthetic diet containing more than 8% protein which consisted of the adequate essential amino acias as casein, in both the exocrine function and the morphologic pattern of the pancreas would he normal.
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